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DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand‐Stacking Interactions
Author(s) -
Brotschi Christine,
Leumann Christian J.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250516
Subject(s) - stacking , dna , biphenyl , hydrogen bond , base pair , chemistry , hydrophobic effect , molecular recognition , crystallography , structural motif , stereochemistry , biochemistry , molecule , organic chemistry
Back to basis : Short DNA duplexes can be packed with at least four hydrophobic, not‐hydrogen‐bonding biphenyl base pairs in the center of the sequence without compromising stability. Recognition of Bph occurrs by interstrand‐stacking interactions as illustrated (X=biphenyl or bipyridyl). This new zipperlike recognition motif opens exciting possibilities for the introduction of new function into double‐helical recognition systems based on the DNA backbone.