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A Virosome‐Mimotope Approach to Synthetic Vaccine Design and Optimization: Synthesis, Conformation, and Immune Recognition of a Potential Malaria‐Vaccine Candidate
Author(s) -
Pfeiffer Bernhard,
Peduzzi Elisabetta,
Moehle Kerstin,
Zurbriggen Rinaldo,
Glück Reinhard,
Pluschke Gerd,
Robinson John A.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200250348
Subject(s) - mimotope , malaria vaccine , virology , circumsporozoite protein , immune system , computational biology , computer science , plasmodium falciparum , malaria , antibody , biology , epitope , immunology
An optimized cyclic peptidomimetic (see picture) of the NPNA‐repeat region in the circumsporozoite (CS) protein of P. falciparum was designed. When delivered to the immune system on human‐compatible viruslike particles (virosomes), the mimetic effectively elicits sporozoite‐binding antibodies. This virosome‐mimotope (virotope) approach may be of general value for the design and testing of new synthetic‐vaccine candidates.