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Evolution in the Palladium‐Catalyzed Cross‐Coupling of sp‐ and sp 2 ‐Hybridized Carbon Atoms
Author(s) -
Tykwinski Rik R.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200201617
Subject(s) - sonogashira coupling , acetylide , palladium , halide , catalysis , aryl , ligand (biochemistry) , coupling reaction , chemistry , coupling (piping) , carbon fibers , combinatorial chemistry , medicinal chemistry , materials science , organic chemistry , biochemistry , alkyl , receptor , metallurgy , composite number , composite material
Palladium‐catalyzed bond‐formation between alkynes and aryl halides and triflates is as fascinating today as it was nearly 30 years ago when such reactions were introduced by Sonogashira (see scheme; OTf=CF 3 SO 3 ). More facile procedures, new acetylide coupling partners, and more efficient catalysts and ligand systems all combine to expand the limits of this versatile reaction.