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Construction of Quaternary Stereocenters: New Perspectives through Enantioselective Michael Reactions
Author(s) -
Christoffers Jens,
Baro Angelika
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200201614
Subject(s) - stereocenter , enantioselective synthesis , michael reaction , quaternary , chemistry , catalysis , organic chemistry , combinatorial chemistry , stereochemistry , geology , paleontology
Pd II ‐catalyzed Michael reactions of β‐dicarbonyl compounds 1 and enones 2 can generate quaternary stereocenters (shown in yellow) with selectivities of 90 % ee at relatively high temperatures (−10 °C). This method represents a breakthrough in enantioselective synthesis.