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Electrospray Ionization Tandem Mass Spectrometry in High‐Throughput Screening of Homogeneous Catalysts
Author(s) -
Chen Peter
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200200560
Subject(s) - electrospray ionization , tandem mass spectrometry , homogeneous , mass spectrometry , throughput , sentence , tandem , chemistry , computer science , chromatography , materials science , physics , telecommunications , artificial intelligence , composite material , wireless , thermodynamics
The frontispiece shows an illustration by John Tenniel and an excerpt from the 1865 edition of Lewis Carroll's “Alice in Wonderland”. Because everything in Wonderland runs counter to logic, the Queen of Hearts declares in Alice's trial “Sentence first—verdict afterwards”. High‐throughput screening of catalysts, as it is conventionally practiced, does “Synthesis first—screening afterwards” which, as is argued in this review, also backwards. Given the particular constraints present in organometallic complexes, it is more efficient to develop a selective synthesis only when it has already been determined that a structure is likely to be better. The consequence is that screening methods must be able to handle ill‐defined mixtures. Electrospray ionization tandem mass spectrometry is presented as a technical solution to this problem.