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Natural Product Hybrids as New Leads for Drug Discovery
Author(s) -
Tietze Lutz F.,
Bell Hubertus P.,
Chandrasekhar Srivari
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200200553
Subject(s) - natural product , hybrid , natural (archaeology) , drug discovery , agrochemical , biochemical engineering , computational biology , microbiology and biotechnology , biology , bioinformatics , engineering , ecology , biochemistry , botany , agriculture , paleontology
Abstract Natural products play an important role in the development of drugs, especially for the treatment of infections and cancer, as well as immunosuppressive compounds. However, the number of natural products is limited, whereas millions of hybrids as combinations of parts of different natural products can be prepared. This new approach seems to be very promising in the development of leads for both medicinal and agrochemical applications, as the biological activity of several new hybrids exceeds that of the parent compounds. The advantage of this concept over a combinatorial chemistry approach is the high diversity and the inherent biological activity of the hybrids.