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A Highly Efficient Aminohydroxylation Process
Author(s) -
Rubin A. Erik,
Sharpless K. Barry
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199726371
Subject(s) - olefin fiber , osmium , scope (computer science) , process (computing) , chemistry , catalysis , combinatorial chemistry , organic chemistry , computer science , programming language , ruthenium
In the absence of external ligands α,β‐unsaturated amides represent one of the few olefin classes which exhibit excellent rates and yields in osmium‐catalyzed aminohydroxylation. The scope of the reaction was examined, and a one‐pot method for the conversion of the hydroxysulfonamides 2 and 3 into the corresponding aziridines 4 developed. Ts = p ‐MeC 6 H 4 SO 2 .