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Comparison of the Bioactive Conformations of Sialyl Lewis X and a Potent Sialyl Lewis X Mimic
Author(s) -
Jahnke Wolfgang,
Kolb Hartmuth C.,
Blommers Marcel J. J.,
Magnani John L.,
Ernst Beat
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199726031
Subject(s) - chemistry , stereochemistry , rational design , biochemistry , nanotechnology , materials science
For the rational design of drugs that inhibit the interaction between E‐selectin and sialyl Lewis X , structural information on bound inhibitors is required. The bioactive conformation of the potent sialyl Lewis X mimic 1 was therefore determined by transfer NOE NMR spectroscopic methods.