Premium
Comparison of the Bioactive Conformations of Sialyl Lewis X and a Potent Sialyl Lewis X Mimic
Author(s) -
Jahnke Wolfgang,
Kolb Hartmuth C.,
Blommers Marcel J. J.,
Magnani John L.,
Ernst Beat
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199726031
Subject(s) - chemistry , stereochemistry , rational design , biochemistry , nanotechnology , materials science
For the rational design of drugs that inhibit the interaction between E‐selectin and sialyl Lewis X , structural information on bound inhibitors is required. The bioactive conformation of the potent sialyl Lewis X mimic 1 was therefore determined by transfer NOE NMR spectroscopic methods.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom