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Polyamides as Artificial Regulators of Gene Expression
Author(s) -
Weisz Klaus
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199725921
Subject(s) - minor groove , dna , gene , imidazole , pyrrole , chemistry , biochemistry , microbiology and biotechnology , computational biology , biology , biophysics , genetics , organic chemistry
Interference with the transcription of specific genes in vivo can be achieved with artificial, low molecular weight pyrrole‐imidazole polyamides, as shown by recent studies by Gottesfeld, Dervan et al. This is possible because these ligands are capable of binding with high affinity and specificity to predetermined DNA sequences in the minor groove of double‐stranded DNA (see schematic representation on the right; gray: pyrrole, black: imidazole units).