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Total Synthesis of Eleutherobin
Author(s) -
Nicolaou K. C.,
van Delft Floris,
Ohshima Takashi,
Vourloumis Dionisios,
Xu Jinyou,
Hosokawa Seijiro,
Pfefferkorn Jeffrey,
Kim Sanghee,
Li Tianhu
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199725201
Subject(s) - total synthesis , chemistry , stereochemistry , combinatorial chemistry , biological activity , biochemistry , in vitro
Taxol‐like activity is exhibited by eleutherobin ( 1 ), one of the most promising antitumor agents isolated from nature in recent years. The first total synthesis of this compound also provided a route to two biologically active analogues, thus enabling the first structure–activity relationships within the eleutherobin family to be established.