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Ion‐Exchange Resins for Combinatorial Synthesis: 2,4‐Pyrrolidinediones by Dieckmann Condensation
Author(s) -
Kulkarni Bheemashankar A.,
Ganesan Arasu
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199724541
Subject(s) - chemistry , ammonium , condensation , ion exchange resin , alkyl , amide , aryl , catalysis , ion exchange , polymer chemistry , organic chemistry , ion , medicinal chemistry , physics , thermodynamics
By temporary immobilization on a quaternary ammonium resin (Amberlyst 26‐A, OH − form), the acidic 2,4‐pyrrolidinediones (tetramic acids) could be purified immediately after being synthesized by a Dieckmann condensation of amide esters that was catalyzed by this resin [Eq. (a)]. R 1 H, alkyl, benzyl; R 2 = phenyl, aryl; R 3 CN, o ‐O 2 NC 6 H 4 , P(O)(OEt) 2 .