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Carbene Complex Modified Glycals: Synthesis and Reactivity
Author(s) -
Dötz Karl Heinz,
Ehlenz Richard,
Paetsch Daphne
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199723761
Subject(s) - carbene , reactivity (psychology) , surface modification , chemistry , chromium , transition metal carbene complex , metal , combinatorial chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
New opportunities in the functionalization of carbohydrates arise from carbene complex modified glycals. They undergo a chromium‐induced benzannulation to give benzoglycals 1 and allow a C 2 ‐homologization to 2 with retention of the metal–carbene bond by a diastereoselective insertion of ynol ethers.