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Anti‐Markovnikov Functionalization of Olefins: Rhodium‐Catalyzed Oxidative Aminations of Styrenes
Author(s) -
Beller Matthias,
Eichberger Martin,
Trauthwein Harald
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199722251
Subject(s) - markovnikov's rule , amination , chemistry , rhodium , aryl , catalysis , alkyl , oxidative phosphorylation , olefin fiber , organic chemistry , surface modification , reductive amination , combinatorial chemistry , regioselectivity , biochemistry
Not the Markovnikov product 4 , but the anti‐Markovnikov product 3 is obtained by the oxidative amination of styrenes 1 with secondary amines 2 . The oxidant in this rhodium‐catalyzed reaction is the olefin itself, which is reduced to the ethylarene 5 . Ar = aryl, R = alkyl, aryl.