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Biosynthesis of Taxol
Author(s) -
Rohr Jürgen
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199721901
Subject(s) - natural product , biosynthesis , taxus , evergreen , chemistry , biology , biochemistry , computational biology , microbiology and biotechnology , botany , enzyme
Taxol, a true “evergreen” in natural product chemistry! Owing to the limited supply of this successful antitumor agent in the bark of yew trees, alternative sources are being sought. Crucial information on its unusual and complex biosynthesis (shown below) has been obtained, and some enzymes responsible have been identified. The long‐term goal is the efficient, biotechnology production of taxol ( 1 ) by fungi or plant tissue cultures.