Palladium‐Catalyzed Allylic Alkylation with Phosphinoaryldihydrooxazole Ligands: First Evidence and NMR Spectroscopic Structure Determination of a Primary Olefin–Pd 0  Complex | Zendy

Steinhagen Henning | Zendy; Reggelin Michael | Zendy; Helmchen Günter | Zendy

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Palladium‐Catalyzed Allylic Alkylation with Phosphinoaryldihydrooxazole Ligands: First Evidence and NMR Spectroscopic Structure Determination of a Primary Olefin–Pd 0 Complex

Author(s) -

Steinhagen Henning,

Reggelin Michael,

Helmchen Günter

Publication year - 1997

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199721081

Subject(s) - allylic rearrangement , palladium , olefin fiber , tsuji–trost reaction , chemistry , ligand (biochemistry) , malonate , catalysis , nucleophile , dimethyl malonate , medicinal chemistry , substitution reaction , double bond , stereochemistry , catalytic cycle , organic chemistry , biochemistry , receptor

Under the 2D NMR spectroscopic magnifying glass: The intermediacy of 1 in the Pd‐catalyzed allylic substitution was investigated and proven. Characterization of this Pd 0 complex, which is primarily formed in the catalytic cycle, shows that attack of the nucleophile malonate at the double bond of the allyl ligand is preferred trans to the P atom.

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