NADH‐Dependent Halogenases Are More Likely To Be Involved in Halometaolite Biosynthesis Than Haloperoxidases | Zendy

Hohaus Kathrin | Zendy; Altmann Annett | Zendy; Burd Wassily | Zendy; Fischer Ilona | Zendy; Hammer Philip E. | Zendy; Hill Dwight S. | Zendy; Ligon James M. | Zendy; van Pée KarlHeinz | Zendy

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NADH‐Dependent Halogenases Are More Likely To Be Involved in Halometaolite Biosynthesis Than Haloperoxidases

Author(s) -

Hohaus Kathrin,

Altmann Annett,

Burd Wassily,

Fischer Ilona,

Hammer Philip E.,

Hill Dwight S.,

Ligon James M.,

van Pée KarlHeinz

Publication year - 1997

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199720121

Subject(s) - pseudomonas fluorescens , tryptophan , biochemistry , regioselectivity , biosynthesis , chemistry , substrate (aquarium) , substrate specificity , enzyme , peroxide , pseudomonas , stereochemistry , organic chemistry , biology , bacteria , catalysis , amino acid , genetics , ecology

NADH instead of hydroged peroxide is required by two newly identified, substrate‐specific and regioselective halogenases. Both were isolated from a pyrrolnitrin‐producing Pseudomonas fluorescens strain. One enzyme catalyzes the chlorination of L ‐tryptophan to 7‐chloro‐ L ‐tryptophan ( 1 ).

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