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Direct Solid‐Phase Glycosylations of Peptide Templates on a Novel PEG‐Based Resin
Author(s) -
Schleyer Axel,
Meldal Morten,
Manat Renil,
Paulsen Hans,
Bock Klaus
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199719761
Subject(s) - glycopeptide , glycosyl , peptide , glycosylation , chemistry , template , glycan , solid phase synthesis , combinatorial chemistry , peg ratio , peptide synthesis , glycoprotein , biochemistry , computer science , programming language , finance , economics , antibiotics
Glycopeptide libraries in which both the carbohydrate part and the peptide part have been varied can be generated by stereoselctive glycosylation of free hydroxy groups of support‐bound peptides with glycosyl trichloroacetimidates. The use of temporary t Bu protecting groups enabled the stereoselctive synthesis of a model library of four glycopeptides (one is depicted on the right) that each have two different glycosyl groups.