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A Five‐Atom Molecule which Enantiomerizes in a Single Step via Chiral Transition States
Author(s) -
Mauksch Michael,
von Ragué Schleyer Paul
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199718561
Subject(s) - pseudorotation , molecule , atom (system on chip) , chemistry , crystallography , transition state , two step , computational chemistry , stereochemistry , combinatorial chemistry , organic chemistry , engineering , catalysis , embedded system
Synthetic chemists are challenged to find a five‐atom molecule that, like cyclo‐SeSSOS, can enantiomerize in a single step without passing through any achiral conformation. The barrier for the pseudorotation of cyclo ‐SeSSOS shown below is computed to be quite low: 6.2 kcal mol −1 .
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