Premium
Conformation Design of a Fully Flexible βII‐ Hairpin Analogue
Author(s) -
Schopfer Ulrich,
Stahl Martin,
Brandl Trixi,
Hoffmann Reinhard W.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199717451
Subject(s) - rational design , hydrogen bond , chemistry , stereochemistry , crystallography , molecule , materials science , nanotechnology , organic chemistry
Almost congruent with the natural prototype 1 , βII‐hairpin mimetic 2 was obtained through rational conformation design. The hydrocarbon backbone of 2 provides optimal preorganization of the hydrogen bond, which is decisive for inducing a β‐sheet conformation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom