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Activity of 2′,5′‐Linked RNA in the Template‐Directed Oligomerization of Mononucleotides
Author(s) -
Prakash Thazha P.,
Roberts Christopher,
Switzer Christopher
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199715221
Subject(s) - rna , template , primer (cosmetics) , linkage (software) , computational biology , chemistry , genetics , biology , nanotechnology , gene , materials science , organic chemistry
A possible prebiotic RNA synthesis has been experimentally modeled with a 2′,5′‐linked RNA template. Mononucleoside 5′‐phosphoroimidazolides are incorporated after a primer, as directed by the unnaturally linked template (shown schematically on the right). The template linkage is not fully conserved in the product.