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Uridine Diphospho‐α‐ D ‐ gluco ‐hexodialdose: Synthesis and Kinetic Competence in the Reaction Catalyzed by UDP‐Glucose Dehydrogenase
Author(s) -
Campbell Robert E.,
Tanner Martin E.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199715201
Subject(s) - chemistry , uridine , catalysis , dehydrogenase , enzyme , biochemistry , stereochemistry , rna , gene
The elusive aldehyde 1 has never been trapped nor detected during the enzymatic oxidation of UDP‐glucose to UDP‐glucuronic acid. Here the synthesis of 1 is reported; it proved to be kinetically competent to serve as an intermediate in the reaction catalyzed by UDP‐glucose dehydrogenase.