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Palladium‐Catalyzed Amidocarbonylation—A New, Efficient Synthesis of N ‐Acyl Amino Acids
Author(s) -
Beller Matthias,
Eckert Markus,
Vollmüller Frank,
Bogdanovic Sandra,
Geissler Holger
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199714941
Subject(s) - palladium , catalysis , chemistry , amino acid , organic chemistry , combinatorial chemistry , biochemistry
For the first time palladium catalysts have been used successfully for the amidocarbonylation reaction. The activity of the cabalt catalysts that were used exclusively beforehand has now been exceeded by an order of magnitude, and the reaction can be performed under far milder conditions. Palladium‐catalyzed amidocarbonylation reactions can now be used for the synthesis of a much wider range of N ‐acyl amino acids.