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N ‐Bromoacetamide—A New Nitrogen Source for the Catalytic Asymmetric Aminohydroxylation of Olefins
Author(s) -
Bruncko Milan,
Schlingloff Gunther,
Sharpless K. Barry
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199714831
Subject(s) - chemistry , catalysis , osmium , nitrogen , organic chemistry , olefin fiber , combinatorial chemistry , ruthenium
The efficient large‐scale synthesis (see below) of an enantiomerically pure Taxol side chain precursor—3‐phenylisoserine ( 1 )—highlights the potential of the third modification of the asymmetric aminohydroxylation (AA). The use of N ‐bromoacetamide as the nitrogen source is the latest advance in the osmium‐catalyzed AA of olefins.