Rapid Synthesis of the Enantiomers of myo ‐Inositol‐1,3,4,5‐tetrakisphosphate by Direct Chiral Desymmetrization of myo ‐Inositol Orthoformate

As controversial as ever is the role of D ‐ myo ‐inositol‐1,3,4,5‐tetrakisphosphate ( 1 ) in intracellular signaling. A new synthetic strategy that makes minimal use of protecting groups allows rapid, direct access not only to pure 1 in the amounts required for cocrystallographic and NMR studies with its recently identified macromolecular targets, but also to the little‐known L enantiomer, which is invaluable as a control in radioligand binding and functional studies.