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Towards Artificial DNA‐Repair Enzymes: Incorporation of a Flavin Amino Acid into DNA‐Binding Oligopeptides
Author(s) -
Carell Thomas,
Butenandt Jens
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199714611
Subject(s) - pyrimidine dimer , dna , flavin group , oligonucleotide , oligopeptide , chemistry , biochemistry , dna binding domain , pyrimidine , enzyme , photolyase , amino acid , dna repair , stereochemistry , transcription factor , peptide , gene
Mimicking DNA photolyases: Model proteins containig the flavin amino acid L ‐ 1 within the DNA‐binding domain of a transcription factor are capable of completely repairing damage from the formation of pyrimidine dimers in single‐stranded oligonucleotides. Cyclobutane pyrimidine dimers are thus photochemically reactivated.