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Biomimetic Extradiol Cleavage of Catechols: Insights into the Enzyme Mechanism
Author(s) -
Ito Masami,
Que Lawrence
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199713421
Subject(s) - catechol , cleavage (geology) , regioselectivity , chemistry , stereochemistry , enzyme , oxidative cleavage , combinatorial chemistry , biochemistry , biology , catalysis , paleontology , fracture (geology)
Quantitative extradiol cleavage of a catechol derivative is achieved by exposure of complex 1 to O 2 in the presence of AgBF 4 and an aromatic nitrogen base. These results provide insight into how the regiochemistry of oxidative cleavage may be controlled by the metal centers of the catechol dioxygenases.