Enzymatic Resolution of Alcohols Coupled with Ruthenium‐Catalyzed Racemization of the Substrate Alcohol | Zendy

Larsson Anna L. E. | Zendy; Persson B. Anders | Zendy; Bäckvall JanE. | Zendy

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Enzymatic Resolution of Alcohols Coupled with Ruthenium‐Catalyzed Racemization of the Substrate Alcohol

Author(s) -

Larsson Anna L. E.,

Persson B. Anders,

Bäckvall JanE.

Publication year - 1997

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199712111

Subject(s) - racemization , ruthenium , kinetic resolution , catalysis , substrate (aquarium) , alcohol , chemistry , resolution (logic) , enzyme , organic chemistry , combinatorial chemistry , enzyme catalysis , enantioselective synthesis , computer science , biology , ecology , artificial intelligence

A specifically designed acyl donor, an efficient enzyme, and a stable and reliable ruthenium catalyst are fundamental for the resolution of the racemic alcohols described here (see scheme on the right). For R 1 Ph and R 2 Me, 100% conversion into the corresponding acetate was achieved with greater than 99.5% ee .

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