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Enzymatic Resolution of Alcohols Coupled with Ruthenium‐Catalyzed Racemization of the Substrate Alcohol
Author(s) -
Larsson Anna L. E.,
Persson B. Anders,
Bäckvall JanE.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199712111
Subject(s) - racemization , ruthenium , kinetic resolution , catalysis , substrate (aquarium) , alcohol , chemistry , resolution (logic) , enzyme , organic chemistry , combinatorial chemistry , enzyme catalysis , enantioselective synthesis , computer science , biology , ecology , artificial intelligence
A specifically designed acyl donor, an efficient enzyme, and a stable and reliable ruthenium catalyst are fundamental for the resolution of the racemic alcohols described here (see scheme on the right). For R 1 Ph and R 2 Me, 100% conversion into the corresponding acetate was achieved with greater than 99.5% ee .