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Synthesis of Enopeptin B from Streptomyces sp RK‐1051
Author(s) -
Schmidt Ulrich,
Neumann Karin,
Schumacher Andreas,
Weinbrenner Stefan
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199711101
Subject(s) - polyene , schematic , natural product , chemistry , stereochemistry , combinatorial chemistry , total synthesis , organic chemistry , engineering , electronic engineering
A cyclopeptolide, a polyene, and an aminoreductone —species with completely different biogenetic origins—are the components of the antibiotically active natural product enopeptin B ( 1 , see schematic representation below), which is particularly active against Staphylococcus aureus . The first total synthesis of this compound, which belongs to a new class of substances, was achieved by the clever use of the arsenal of methods available to modern peptide chemistry. The three basic units were coupled by two different routes.