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Protein Synthesis by Chemical Ligation of Unprotected Peptides in Aqueous Solution
Author(s) -
Walker Michael A.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199710691
Subject(s) - native chemical ligation , ligation , chemical ligation , chemistry , side chain , combinatorial chemistry , aqueous solution , chemical synthesis , group (periodic table) , chemical biology , peptide , organic chemistry , biochemistry , biology , microbiology and biotechnology , in vitro , polymer
Orthogonal and native chemical ligation are two terms of a novel method for synthesizing proteins. It is particularly useful where molecular biology techniques fail, for example, for the synthesis of analogs of natural proteins from unnatural building blocks. Since the innovative method proceeds without carboxyl‐group activation or side‐chain protection, it is very easy to use and will find application by the average organic chemist.