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Cation‐Cyclization Selectivity: Variable Structures of Protonated Cyclopropanes and Selectivity Control by Catalytic Antibodies
Author(s) -
Lee Jeehiun K.,
Houk Kendall N.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199710031
Subject(s) - selectivity , cyclopropane , protonation , chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , ring (chemistry) , ion
A nonclassical, protonated cyclopropane is the intermediate formed in an antibodycatalyzed cyclization reaction. The selectivity in favor of the cyclopropane product is increased upon binding of the catalytic antibody, which amplifies the inherent preference for one reaction pathway.