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Design of Antisense (Complementary) Peptides as Selective Inhibitors of Cytokine Interleukin‐1
Author(s) -
Davids Joseph W.,
ElBakri Ali,
Heal Jonathan,
Christie Gary,
Roberts Gareth W,
Raynes John G.,
Miller Andrew D.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199709621
Subject(s) - sense (electronics) , gene isoform , receptor , peptide , chemistry , dna , interleukin , cytokine , biology , microbiology and biotechnology , biochemistry , gene , immunology
The ability of sense peptides (coded for by sense DNA) and corresponding antisense peptides (coded for by corresponding antisense DNA) to interact specifically was used to design antisense peptide inhibitors of interleukin‐1 isoforms IL‐1β and IL‐1α. These inhibitors appear to act as “mini receptors”, binding to both isoforms and thereby sterically blocking the normal interaction between interleukin‐1 and its receptors.