Premium
Pyranosyl‐RNA Also Forms Hairpin Structures
Author(s) -
Micura Ronald,
Bolli Martin,
Windhab Norbert,
Eschenmoser Albert
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199708701
Subject(s) - rna , duplex (building) , stacking , nucleotide , nucleic acid structure , base pair , stereochemistry , chemistry , dna , biochemistry , gene , organic chemistry
A minimum of three nucleotides in the loop are necessary for p‐RNA oligomers to assume a hairpin rather than a duplex structure. Such hairpin structures form with comparable ease, as they do in RNA, in spite of the (conjectured) higher rigidity of the p‐RNA backbone. Base stacking in p‐RNA duplexes is interstrand rather than intrastrand; therefore, dangling bases enhance duplex stability when they are at the 2′‐end (and not at the 4′‐end).