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A Synthetic Receptor Selective for Citrate
Author(s) -
Metzger Axel,
Lynch Vincent M.,
Anslyn Eric V.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199708621
Subject(s) - steric effects , hydrogen bond , chemistry , receptor , combinatorial chemistry , citric acid , stereochemistry , molecule , biochemistry , organic chemistry
Applied molecular recognition —strong and selective binding of citrate in highly competitive media such as water and orange juice is reported. Five steps are enough to synthesize receptor 1 that is complementary in charge and shape of citrate. Electrostatic interactions and a network of hydrogen bonds, preorganized by steric effects, are the design principles responsible for the binding of receptor and citrate [Eq. (a)].
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