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Asymmetric Dihydroxylation with MeO‐Polyethyleneglycol‐Bound Ligands
Author(s) -
Bolm Carsten,
Gerlach Arne
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199707411
Subject(s) - dihydroxylation , ligand (biochemistry) , homogeneous , catalysis , chemistry , homogeneous catalysis , metal , organic chemistry , combinatorial chemistry , stereochemistry , enantioselective synthesis , biochemistry , mathematics , receptor , combinatorics
Homogenous catalysis as long as it is needed : the advantages of homogeneous and heterogeneous metal catalysis can be combined by attachment of an alkaloid ligand to polyethyleneglycol methylmonoether. Diols with up to 99% ee have been obtained in the asymmetric Sharpless dihydroxylation of olefins with the polymer modified ligand 1 (DHQD = dihydroquinidine).