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Cross‐Linked Enzyme Crystals (CLECs): Efficient and Stable Biocatalysts for Preparative Organic Chemistry
Author(s) -
Zelinski Thomas,
Waldmann Herbert
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199707221
Subject(s) - chemistry , enzyme , covalent bond , aqueous solution , biocatalysis , organic chemistry , enzyme catalysis , combinatorial chemistry , stereochemistry , catalysis , reaction mechanism
Enzyme preparations that are stable in organic solvents and in aqueous media can be obtained by covalently cross‐linking enzyme crystals. The resulting exceptionally stable biocatalysts, the “cross‐linked enzyme crystals” (CLECs), efficiently catalyze enzymatic peptide syntheses (see example below), esterfications, hydrolyses, CC bond‐forming reactions, and reductions. Z = benzyloxycarbonyl.