Premium
Stability and Conformational Switching in a Mini‐Cyclic Oligonucleotide Conjugate
Author(s) -
Herrlein Mathias K.,
Letsinger Robert L.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199705991
Subject(s) - conjugate , oligonucleotide , ring (chemistry) , chemistry , excimer , base (topology) , crystallography , nucleotide , alkali metal , stereochemistry , fluorescence , mathematics , dna , physics , organic chemistry , biochemistry , optics , mathematical analysis , gene
A remarkably stable base‐stacked structure is shown by the 70‐membered ring 2 , which possesses only four nucleotide bases and is formed by efficient cyclization of the oligonucleotide conjugate 1 . In the presence of alkali, 2 twists to bring the stilbene groups into close proximity, as indicated by an excimer emission upon irradiation.