Premium
Total Synthesis of Epothilone A: The Macrolactonization Approach
Author(s) -
Nicolaou K. C.,
Sarabia Francisco,
Ninkovic Sacha,
Yang Zhen
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199705251
Subject(s) - epothilones , epothilone , total synthesis , computer science , key (lock) , stereochemistry , chemistry , operating system
This highly convergent and practical total synthesis of the antitumor agent epothilone A uses a macrolactonization (see below) as the key step. The strategy may provide access to a variety of epothilones desirable for biological screening.