Premium
Total Synthesis of Epothilone A: The Macrolactonization Approach
Author(s) -
Nicolaou K. C.,
Sarabia Francisco,
Ninkovic Sacha,
Yang Zhen
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199705251
Subject(s) - epothilones , epothilone , total synthesis , computer science , key (lock) , stereochemistry , chemistry , operating system
This highly convergent and practical total synthesis of the antitumor agent epothilone A uses a macrolactonization (see below) as the key step. The strategy may provide access to a variety of epothilones desirable for biological screening.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom