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Synthesis and Characterization of Photolabile Compounds Releasing Noracetylcholine in the Microsecond Time Range
Author(s) -
Peng Ling,
Wirz Jakob,
Goeldner Maurice
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199703981
Subject(s) - microsecond , chemistry , acetylcholine , acetylcholinesterase , kinetics , combinatorial chemistry , hydrolysis , derivative (finance) , stereochemistry , enzyme , organic chemistry , physics , medicine , quantum mechanics , astronomy , financial economics , economics , endocrinology
The rapid and efficient photochemical release of noracetylcholine 2 , and analogue of the neurotransmitter acetylcholine, from its precursor 1 makes this probe well‐suited for a dynamic study of the mechanism of hydrolysis of acetylcholine by acetylcholinesterase. The nitrobenzyl derivative 1 , the most promising candidate for time‐resolved crystallographic studies of this rapid enzyme, displays the required photo‐fragmentation kinetics in the microsecond time‐range and inhibitory properties oacetylcholinesterase.