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New Sequential Reactions with Single‐Electron‐Donating Agents
Author(s) -
Skrydstrup Troels
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199703451
Subject(s) - tetrathiafulvalene , ring (chemistry) , transformation (genetics) , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , molecule , biochemistry , gene
Complex polycyclic ring systems related to those of many natural products can be prepared from readily accessible starting materials by novel sequential reactions promoted by either SmI 2 or tetrathiafulvalene. Combinations of anionic and radical steps are possible, as in, for example, the SmI 2 ‐promoted transformation of 1 into 2 with twofold cyclization, which was described by Molander and Harris. TBS = t BuSiMe 2 , TMS = Me 3 Si, HMPA = (Me 3 N) 2 PO.