Highly Selective Allylic Alkylation with a Carbon Nucleophile at the More Substituted Allylic Terminus Catalyzed by an Iridium Complex: An Efficient Method for Constructing Quaternary Carbon Centers | Zendy

Takeuchi Ryo | Zendy; Kashio Mikihiro | Zendy

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Highly Selective Allylic Alkylation with a Carbon Nucleophile at the More Substituted Allylic Terminus Catalyzed by an Iridium Complex: An Efficient Method for Constructing Quaternary Carbon Centers

Author(s) -

Takeuchi Ryo,

Kashio Mikihiro

Publication year - 1997

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199702631

Subject(s) - nucleophile , allylic rearrangement , iridium , tsuji–trost reaction , catalysis , alkylation , carbon fibers , quaternary carbon , chemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , computer science , algorithm , composite number

The selective construction of quaternary carbon centers , which are frequently found in natural products, is essential to many syntheses. A new method relying on the iridium complex [Ir(cod)Cl] 2 as the catalyst can be used for the allylic alkylation of acyclic compounds 1 [Eq (a)]. The products are obtained in yields between 70 and 85% and with a selectivity of 100%. cod = cyclooctadiene.

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