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A New Asymmetric Formylation of Aldehydes
Author(s) -
Kirschning Andreas,
Dräger Gerald,
Jung Alexander
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199702531
Subject(s) - formylation , sharpless asymmetric dihydroxylation , ketene , wittig reaction , chemistry , enantiomer , dihydroxylation , enantioselective synthesis , aldehyde , organic chemistry , sequence (biology) , stereochemistry , catalysis , biochemistry
Efficient asymmetric formylation of aldehydes is possible by Horner–Wittig homologation of aldehydes and subsequent Sharpless asymmetric dihydroxylation of the intermediate prochiral ketene acetals 2 . As is demonstrated for compounds 1 , this novel sequence allows synthesis of α‐hydroxy carboxylates 3 in high enantiomeric purity.