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Total Synthesis of Epothilone A: The Olefin Metathesis Approach
Author(s) -
Yang Zhen,
He Yun,
Vourloumis Dionisios,
Vallberg Hans,
Nicolaou K. C.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199701661
Subject(s) - epothilones , epothilone , olefin metathesis , total synthesis , combinatorial chemistry , metathesis , salt metathesis reaction , chemistry , stereochemistry , organic chemistry , polymerization , polymer
A flexible alterative route to the total synthesis of the antitumor agent epothilone A ( 1 , see below) has been achieved by a highly convergent strategy involving olefin metathesis as a key step. The strategy may allow the chemical synthesis of a library of designed epothilones for biological screening.