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Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine
Author(s) -
Ragupathi Govindaswami,
Park Tae Kyo,
Zhang Shengle,
Kim In Jong,
Graber Linda,
Adluri Sucharita,
Lloyd Kenneth O.,
Danishefsky Samuel J.,
Livingston Philip O.
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199701251
Subject(s) - immunization , antibody , antigen , immune system , immunology , cancer , immunity , breast cancer , human breast , biology , genetics
Of mice and men : A vaccine composed of the fully synthetic globo H human breast tumor antigen 1 and a carrier protein elicits the formation of IgM antibodies in mice. These antibodies bind to MCF‐7 breast cancer cells and trigger effective complement‐mediated cell lysis. These promising results from the immune system of the mouse prompts a strategy to foster active immunity in humans.