Hydroxyamines as a New Motif for the Molecular Recognition of Phosphodiesters: Implications for Aminogloycoside–RNA Interactions | Zendy

Hendrix Martin | Zendy; Alper Phil B. | Zendy; Priestley E. Scott | Zendy; Wong ChiHuey | Zendy

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Hydroxyamines as a New Motif for the Molecular Recognition of Phosphodiesters: Implications for Aminogloycoside–RNA Interactions

Author(s) -

Hendrix Martin,

Alper Phil B.,

Priestley E. Scott,

Wong ChiHuey

Publication year - 1997

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199700951

Subject(s) - chemistry , neomycin , rna , hydrogen bond , aminoglycoside , aqueous solution , antibiotics , stereochemistry , combinatorial chemistry , denticity , molecule , biophysics , biochemistry , crystallography , biology , crystal structure , organic chemistry , gene

Particularly stable complexes with bidentate binding are formed between 1,3‐hydroxyamines and dimethylphosphate, which serve as models of the complexes formed by aminoglycoside antibiotics such as neomycin B ( 1 ) and RNA phosphodiesters. This recognition motif involving a hydrogen bond with the hydroxyl group is also found in the complexation of anions by simple aminoglycosides in aqueous solution.

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