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Cover Picture (Angew. Chem. Int. Ed. Engl. 1/2/1997)
Publication year - 1997
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199700011
Subject(s) - epitope , chemistry , cover (algebra) , computer science , library science , computational biology , microbiology and biotechnology , stereochemistry , antibody , biology , genetics , engineering , mechanical engineering
The cover picture shows the formula of globo H‐KLH in the center, which show the strongest immunological activity in the presence of the immununological adjuvant QS‐21. Globo H‐KLH is a conjugate of the hexasaccharide globo H and hemocyanin from Megathura crenulata . Antibodies against globo H‐KLH—the syringe reminds us that their formation is induced in mice—recognize the globo H epitope on the surface of breast cancer cells and activate the complement system to initiate lysis of the tumor cells. The sugar epitope of globo H was synthesized from glycal units (shown schematically at the top of the picture) and linked with KLH. The transfer of the immunization strategy to humans is the next step in the project that Danishefsky, Livingston, et al. report on page 125 ff (graphics: G. Schulz, Fussgönheim, Germany).