Monitoring the Reaction Progress in Combinatorial Chemistry:  1 H MAS NMR Investigations on Single Macro Beads in the Suspended State | Zendy

Pursch Matthias | Zendy; Schlotterbeck Götz | Zendy; Tseng LiHong | Zendy; Albert Klaus | Zendy; Rapp Wolfgang | Zendy

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Monitoring the Reaction Progress in Combinatorial Chemistry: 1 H MAS NMR Investigations on Single Macro Beads in the Suspended State

Author(s) -

Pursch Matthias,

Schlotterbeck Götz,

Tseng LiHong,

Albert Klaus,

Rapp Wolfgang

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199628671

Subject(s) - magic angle spinning , chemistry , hydantoin , solid state nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , spinning , analytical chemistry (journal) , combinatorial chemistry , nanotechnology , materials science , stereochemistry , polymer chemistry , chromatography , organic chemistry , physics , nuclear magnetic resonance

Laborious cleavage and isolation steps are avoided! The method of 1 H magic angle spinning (MAS) NMR spectroscopy can be used to monitor the course of the synthesis on a single resin particle in a suspended sample in the nanoliter detection range. This extremely useful technique for combinatorial chemistry was tested on a hydantoin reaction sequence.

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