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Monitoring the Reaction Progress in Combinatorial Chemistry: 1 H MAS NMR Investigations on Single Macro Beads in the Suspended State
Author(s) -
Pursch Matthias,
Schlotterbeck Götz,
Tseng LiHong,
Albert Klaus,
Rapp Wolfgang
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199628671
Subject(s) - magic angle spinning , chemistry , hydantoin , solid state nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , spinning , analytical chemistry (journal) , combinatorial chemistry , nanotechnology , materials science , stereochemistry , polymer chemistry , chromatography , organic chemistry , physics , nuclear magnetic resonance
Laborious cleavage and isolation steps are avoided! The method of 1 H magic angle spinning (MAS) NMR spectroscopy can be used to monitor the course of the synthesis on a single resin particle in a suspended sample in the nanoliter detection range. This extremely useful technique for combinatorial chemistry was tested on a hydantoin reaction sequence.