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The Ca 2+ Ion as a Cofactor for a Novel RNA‐Cleaving Deoxyribozyme
Author(s) -
Faulhammer Dirk,
Famulok Michael
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199628371
Subject(s) - deoxyribozyme , cofactor , dna , rna , chemistry , yield (engineering) , enzyme , ion , in vitro , biochemistry , hydrolysis , gene , organic chemistry , materials science , metallurgy
In vitro selection experiments yield unexpected results. An RNA‐cleaving DNA enzyme that was selected in the presence of Mg 2+ ions is much more efficient with Ca 2+ as the cofactor. The result is even more surprising because of the lower hydrolytic efficiency of Ca 2+ itself.
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