Substrate‐Directed Diastereoselective Hydroformylation of Methallylic Alcohols | Zendy

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Substrate‐Directed Diastereoselective Hydroformylation of Methallylic Alcohols

Author(s) -

Breit Bernhard

Publication year - 1996

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.199628351

Subject(s) - hydroformylation , polyketide , substrate (aquarium) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , rhodium , enzyme , biology , biosynthesis , ecology

A reversibly coordinating auxiliary is the key to the first highly diastereo‐selective hydroformylation of acyclic methallylic alcohols ( syn:anti up to 96:4; in the representation on the right the auxiliary is shown as a sphere). The reaction can be used for the efficient construction of stereotriades, the central structural units of polyketide natural products. R is, for example, Ph, CO 2 Me, Me, CH 2 Ph.

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