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Substrate‐Directed Diastereoselective Hydroformylation of Methallylic Alcohols
Author(s) -
Breit Bernhard
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199628351
Subject(s) - hydroformylation , polyketide , substrate (aquarium) , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , rhodium , enzyme , biology , biosynthesis , ecology
A reversibly coordinating auxiliary is the key to the first highly diastereo‐selective hydroformylation of acyclic methallylic alcohols ( syn:anti up to 96:4; in the representation on the right the auxiliary is shown as a sphere). The reaction can be used for the efficient construction of stereotriades, the central structural units of polyketide natural products. R is, for example, Ph, CO 2 Me, Me, CH 2 Ph.