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Recognition of the Helical Sense of Polypeptides by a Chiral Metalloporphyrin Receptor
Author(s) -
Konishi Katsuaki,
Kimata Shuichi,
Yoshida Kiyoko,
Tanaka Masanobu,
Aida Takuzo
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199628231
Subject(s) - porphyrin , chemistry , stereochemistry , receptor , sense (electronics) , protein secondary structure , chirality (physics) , crystallography , biochemistry , physics , chiral symmetry , quantum mechanics , nambu–jona lasinio model , quark
The secondary structure is of primary importance! The D and L forms of α‐helical poly(glutamic acid) (PGA) are complexed selectively by the ( R ) and ( S ) isomers, respectively, of the porphyrin‐based, chiral receptor 1 , which has a xylylenediamide strap. Helical polypeptides can thus be separated by complexation with enantiomerically pure 1 .