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Total Synthesis of (–)‐Epothilone A
Author(s) -
Balog Aaron,
Meng Dongfang,
Kamenecka Ted,
Bertinato Peter,
Su DaiShi,
Sorensen Erik J.,
Danishefsky Samuel J.
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199628011
Subject(s) - epothilone , total synthesis , ring (chemistry) , stereochemistry , epothilones , chemistry , condensation , organic chemistry , geography , meteorology
An audacious macroaldolization is the key step in the first total synthesis of the cytotoxic epothilone A, which starts with the units 1 , 2 , and 3 . This condensation closes the ring to form the macrolide, whose structure was determined and published (also in Angewandte Chemie ) as recently as July 1996.
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